The independently controlled double gates enable the device to achieve an on/off ratio of 10 6 with a low subthreshold swing of 94.3 mV dec −1 while presenting a
Abstract. Caveolin-1 (Cav-1) is a trans-membrane protein that is a major component of the caveolae structure on the plasma membrane. Cav-1 is involved in the regulation of various cellular processes, including cell growth, differentiation, endocytosis, and in particular it has been implied in cellular senescence.
The versatile functions of OsALDH2B1 provide an example of the genic basis of growth–defense trade-offs in plants and may also have important implication for crop genetic improvement by exploring and modulating these components to achieve a balance between high yield and disease resistance. Significance Crops'' defense
1000 Intrinsically Disordered Proteins LEA proteins: IDPs with versatile functions in cellular dehydration tolerance Dirk K. Hincha1 and Anja Thalhammer Max-Planck-Institut f¨ur Molekulare
The solute/sodium symporter family (SSS family; TC 2.A.21; SLC5) consists of integral membrane proteins that use an existing sodium gradient to drive the uphill transport of various solutes, such as sugars, amino acids, vitamins, or ions across the membrane. This large family has representatives in all three kingdoms of life. The human
Although they are widely assumed to play crucial roles in cellular dehydration tolerance, their physiological and biochemical functions are largely unknown. Most LEA proteins are predicted to be intrinsically disordered and this has been experimentally verified in several cases. In addition, some LEA proteins partially fold, mainly into α
Abstract. The development of a pronounced iliotibial band (ITB) is an anatomically distinct evolution of humans. The mechanical behaviour of this "new" structure is still poorly understood and hotly debated in current literature. Iliotibial band syndrome (ITBS) is one of the leading causes of lateral knee pain injuries in runners.
The versatile functions of OsALDH2B1 provide an example of the genic basis of growth–defense trade-offs in plants. Sign up for PNAS alerts. Get alerts for new articles, or get an alert when an article is cited. Manage alerts Growth, development, reproduction, and
The indispensable role of C3 in opsonic phagocytosis as well as in the regulation of humoral immune response is known for long, while the involvement of complement in T-cell biology have been revealed in the past few years. In this review, we discuss the immune modulatory functions of C3-derived fragments focusing on their role in processes
Abstract. Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range of physiological functions and pathological modifications.
Here we summarize our current understanding of the versatile physiological functions of the plant GSK3-like kinases along with their confirmed and potential substrates. AB - The plant glycogen synthase kinase 3 (GSK3)-like kinases are highly conserved protein serine/threonine kinases that are grouped into four subfamilies.
The anterior cingulate cortex (ACC) is located on the medial wall of the cerebral hemisphere in humans and non-human primates, and has well developed intracortical and subcortical connections. Recent brain-imaging studies have suggested the possible involvement of the ACC in a variety of cognitive and motor-related functions.
At the first synapse of the visual system, information flow from photoreceptors to bipolar cells is modulated by horizontal cells (HCs), however, their functional contribution to retinal output and individual visual function is not fully understood. In the current study, we investigated functional roles for HCs in retinal
Chen and colleagues investigated the function of the M-locus protein kinase (MLPK) BnaMLPKs, the functional homolog of BrMLPKs in Brassica rapa []. Chen and colleagues used Arabidopsis as a model to study the role of DPA4 and SOD7 genes in seed development and response to abiotic stress [ 21 ].
adjective. approving uk / ˈvɜː.sə.taɪl / us / ˈvɝː.sə.t̬ ə l / Add to word list. C2. able to change easily from one activity to another or able to be used for many different purposes.
Advanced computing technologies such as distributed computing and the Internet of Things require highly integrated and multifunctional electronic devices. Beyond the Si technology, 2D-materials-based dual-gate transistors are expected to meet these demands due to the ultra-thin body and the dangling-bond-free surface. In this work, a
Abstract. Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus
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Abstract. Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non-small cell lung cancer (NSCLC) patient samples/cell lines and STAT3 inhibition in NSCLC cell lines markedly impairs their survival. STAT3 also plays a pivotal role in driving tumor-promoting inflammation and evasion of anti-tumor
Three decades after its initial discovery, IL-6 still proves to be a surprisingly versatile regulator of physiology and disease (Figure 1). Despite numerous efforts to
A molecular function of nuclear actin for allosteric regulation of remodelers. ATP-dependent chromatin remodelers are enigmatic macromolecular machines that govern the arrangement and composition of nucleosomes across eukaryotic genomes. Here, we review the recent breakthrough provided by cryo-electron
Li, K.W. et al. Physiological and interactomic analysis reveals versatile functions of Arabidopsis 14-3-3 quadruple mutants in response to Fe deficiency. Sci Rep 11, 15551 (2021) .
Abstract. The solute/sodium symporter family (SSS family; TC 2.A.21; SLC5) consists of integral membrane proteins that use an existing sodium gradient to drive the uphill transport of various solutes, such as sugars, amino acids, vitamins, or ions across the membrane. This large family has representatives in all three kingdoms of life.
Bryophytes, including liverworts, mosses, and hornworts, are gametophyte-dominant land plants that are derived from a common ancestor and underwent independent evolution from the sporophyte-dominant vascular plants since their divergence. The plant hormone auxin has been shown to play pleiotropic roles in the haploid bodies of bryophytes.
A novel concept of Janus polarization multiplexed circularly polarized (CP) metadevices is proposed to afford an alternative avenue toward versatility and capacity limit of integrated functions. Six polarization-division channels are engineered by synergizing space division and polarization division based on developed generalized spin-decoupling
m6A, a conserved and abundant modification on RNA, regulates RNA processing and function. RNA m6A machinery, including writers, erasers, and readers
The manuscripts by Narayan et al. and Irobi et al. provide snapshots of gelsolin domains activated by calcium and in complex with the actin monomer, revealing
Members of casein kinase 1 (CK1) are evolutionarily conserved eukaryotic protein kinases, which play fundamental roles in various cellular, physiological and developmental processes. One of the key mechanisms by which the activity of these multifunctional CK1 members is controlled appears to be their specific spatiotemporal
m6A, a conserved and abundant modification on RNA, regulates RNA processing and function. RNA m6A machinery, including writers, erasers, and readers of m6A, is indispensable for m6A installation and function. Intriguingly, recent studies have revealed that m6A machinery can be recruited to chromatin by pleiotropic factors,
Auxin biology in bryophyta: A simple platform with versatile functions. Cold Spring Harbor perspectives in biology . 2021 Mar;13(3):1-22. a040055. doi: 10.1101/cshperspect.a040055 Powered by Pure, Scopus & Elsevier Fingerprint Engine™
A concise overview ofSTAT3''s versatile roles in NSCLC is provided and the yins and yangs of STAT3 targeting therapies are discussed, which include targeting of upstream regulators such as Interleukin-6 (IL-6) or Janus kinase 1/2 (JAK1/2). Signal Transducer and Activator of Transcription 3 (STAT3) activation is frequently found in non
With this counterintuitive recipe, they successfully reported multiplexed functions, i.e., emission of complex vortices and diode-like optical switching devices that manipulates spin lights.
Abstract. NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting conditions. Over the past fifteen years, NLRX1 has been proposed to regulate multiple cellular processes, including antiviral immunity, apoptosis, reactive
A family of cysteine (Cys)-rich, intracellular, and low-molecular-weight (4–8 kDa) MTs are proteins found in nearly all phyla including plants, animals, and fungi, and they have the potential to scavenge reactive oxygen species and detoxify toxic metals including copper, cadmium, and zinc. Based on their Cys numbers and residues, MTs have
In this Review, we document the basic properties of alginate, their chemical modification strategies, and the recent development of alginate-based
The p53 tumor suppressor plays a pivotal role in multicellular organism by enforcing benefits of the organism over those of an individual cell. The task of p53 is to control the integrity and correctness of all processes in each individual cell and in the organism as a whole. Information about the state of ongoing events in the cell is gathered
Abstract. Owing to its abundance in inflammatory settings, interleukin IL-6 is frequently viewed as a proinflammatory cytokine, with functions that parallel those of tumor necrosis factor (TNF) and IL-1β in the context of inflammation. However, accumulating evidence points to a broader role for IL-6 in a variety of (patho)physiological
In this short review, we attempt to give a flavor for the diversity of functional RNAs in the cell and highlight, using selected examples, two quite distinct activities,
Janus Reflective Polarization-Division Metadevices With Versatile Functions Abstract: A novel concept of Janus polarization multiplexed circularly